Anti-Bcl-2 antibodies, mouse

Anti-Bcl-2 antibodies, mouse

Clone: REA356 | Dilution: 1:50
Clone REA356 recognizes the mouse Bcl-2 antigen, a 26 kDa intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is the founding member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor.
Additional information: Clone REA356 displays negligible binding to Fc receptors.

Alternative names

BCL2, Apoptosis regulator Bcl-2

Technical specifications

  • Antigen: Bcl-2
  • Clone: REA356
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: BCL2, Apoptosis regulator Bcl-2
  • Entrez Gene ID: 12043
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Dunkle, A. et al. (2013)
      Transfer of CD8
      +
      T cell memory using Bcl-2 as a marker.
      J. Immunol. 190(3): 940-947
    2. Czabotar, P. E. et al. (2014) Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15(1): 49-63
    3. Negrini, M. et al. (1987) Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49(4): 455-463
Product options: 1
30 µg in 200 µL (1)
EUR  90,00

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