Anti-Siglec-F MicroBeads, mouse

Anti-Siglec-F MicroBeads, mouse

The Anti-Siglec-F MicroBeads, mouse have been developed for the positive selection or depletion of cells expressing mouse Siglec-F antigen from mouse peripheral blood (eosinophils, minor fraction of neutrophils) or mouse lung single-cell suspensions (eosinophils and alveolar macrophages).

Background information

Siglec-F, also known as Siglec-5, is a member of the sialic acid-binding immunoglobulin (Ig)-like lectins (Siglecs). The extracellular Ig domain binds specifically carbohydrate structures containing sialic acid residues. Siglec-F has, like most Siglecs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain and is discussed to play a role in eosinophil accumulation and survival. It is expressed in a tissue dependent manner on most eosinophils, but also found on alveolar macrophages and some neutrophils.
  • Selected references

    1. Zhang, M. et al. (2007)
      Defining the
      in vivo
      function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
      Blood 109(10): 4280-4287
    2. Guo, J. P. et al. (2011) Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am. J. Respir. Cell Mol. Biol. 44(2): 238-243
    3. Bochner, B. (2009) Siglec-8 on human eosinophils and mast cells, and Siglec-Fon murine eosinophils, are functionally related inhibitory receptors. Clin. Exp. Allergy 39(3): 317-324
Product options: 1
for 1×
10
9
total cells
(1) or for 2×
10
9
cells
(2)
EUR  630,00