MACSxpress® Technology

Untouched cell isolation directly from blood products

  • Untouched cell isolation from whole blood, buffy coat, or LRSC in 25 min
  • No density gradient centrifugation needed
  • Minimal sample manipulation

MACSxpress Technology is a cell separation platform specially designed for processing large volumes of blood and blood products. It is the fastest, easiest, and most convenient way to isolate viable and functional immune cells directly from blood sources – without the need for density gradient centrifugation.

The technology is based on micro-sized MACSxpress Beads allowing the removal of non-target cells by immunomagnetic depletion using the MACSxpress Separator, a powerful permanent magnet. Simultaneously, erythrocytes are sedimented, yielding untouched target cells of high purity.

Basic principle

MACSxpress Technology
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With MACSxpress Technology, untouched human leukocyte subsets can be isolated from up to 30 mL of blood and blood products. Non-target cells are removed by immunomagnetic depletion using MACSxpress Beads. Simultaneously, erythrocytes are sedimented, yielding untouched target cells of high purity.


Immune cell isolation from whole blood using MACSxpress Technology
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Reliable cell isolation with MACSxpress Isolation Kits

B cells, T cells, and NK cells were isolated from 6 different donors using the MACSxpress Isolation Kits. Purities and recoveries were assessed by flow cytometry using a MACSQuant® Analyzer.

Time comparison of MACSxpress Technology vs. density gradient centrifugation and competitor technology.
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Time savings with MACSxpress Technology

A leukocyte subset isolation with MACSxpress Technology takes less time than a preparative gradient centrifugation.


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MACSxpress Isolation Kits – untouched cell separation from whole blood

Download the brochure to get all the details on our MACSxpress Technology.

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Scientific poster
Untouched isolation of functionally unaffected neutrophils from whole blood

Claudia Zyntek, Jürgen Schmitz, and Gregor Winkels Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

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Scientific report
MACSxpress Technology allows isolation of B cells with high purity for sensitive and concordant microarray-based gene expression profiling

Angela Mekes, Stephanie Soltenborn, Ines Dischinger, Volker Huppert, and Bernhard Gerstmayer, Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

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