Mouse SCF

Mouse SCF

SCF stands for stem cell factor, also termed c-Kit ligand. Mouse SCF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse SCF may be used for a variety of applications, including:
  • In vitro culture and expansion of hematopoietic progenitor cells.
  • Colony formation assays.
  • Differentiation of ES-derived cells towards the hematopoietic lineage.
  • Mast cell differentiation and maintenance.
  • Investigation of receptor signaling.

Alternative names

c-kit ligand, steel factor, MGF

Background information

Stem cell factor (SCF), also known as c-kit ligand, is a hematopoietic growth factor important for the survival, proliferation, and differentiation of hematopoietic stem cells and progenitor cells. Besides its pivotal role in mast cell development, SCF acts as a potent mast cell chemoattractant and upregulates mast cell adhesion and migration. SCF signals through the c-kit receptor (CD117) and exists in two forms, cell surface bound SCF and soluble SCF. The secreted soluble form of SCF is produced by the proteolytic processing of the cell surface anchored precursor molecule. Recombinant Mouse SCF corresponds to the secreted soluble form.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of TF-1 cells
  • premium grade: ≥ 4×
    10
    4
    U/mg
  • research grade: ≥ 2×
    10
    4
    U/mg
  • Selected references

  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 6
E. coli
10 µg
EUR  138,00
E. coli
25 µg
EUR  215,00
E. coli
10 µg
EUR  169,00
E. coli
25 µg
EUR  272,00
E. coli
100 µg
EUR  538,00
E. coli
1000 µg
EUR  2.276,00