Human LIF

Human LIF

Human LIF stands for leukemia inhibitory factor. Human LIF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.


Human LIF may be used for a variety of applications, including:
  • Study of reprogramming and maintenance of human iPS cells to a naive-like stage.
  • Investigation of hematopoiesis, bone and neural development.

Background information

Leukemia inhibitory factor (LIF) is a pleiotropic cytokine, which is critically involved in embryonic development and blastocyst implantation. LIF belongs to the interleukin 6 family and functions through the gp130 activation of STAT3. It is a key factor that prevents embryonic stem cells (ESC) to differentiate, and it is used for maintenance of ES and iPS cultures, especially in mouse cultures. In human, LIF has a role in the reprogramming and mantainance of ES cells to a naive-like stage. Additionally, LIF affects hematopoiesis, neural development, bone and energy metabolism, and inflammation.

Biological activity

  • Proliferation of human TF-1 cells
  • research grade: ≥ 1×
  • Selected references

    1. Barral, S. et al. (2013)
      Efficient neuronal
      in vitro
      in vivo
      differentiation after immunomagnetic purification of mESC derived neuronal precursors.
      Stem Cell Res. 10(2): 133-46
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Product options: 4
E. coli
5 µg
EUR  56,00
E. coli
25 µg
EUR  195,00
E. coli
100 µg
EUR  723,00
E. coli
1000 µg
EUR  2.875,00