Human IGF-BP3

Human IGF-BP3

IGF-BP3 stands for insulin-like growth factor binding protein 3. Human IGF-BP3 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Alternative names

IBP-3

Background information

IGF-BP3 stands for insulin-like growth factor–binding protein 3. It is the primary IGF-binding protein stabilizing IGF-I as well as IGF-II and regulating their interaction with receptors. Besides its role for transporting IGF, IGF-BP3 has been shown to modulate EGF-EGFR–mediated cell growth, apoptosis, autophagy, and adipogenesis. Implications for a role of IGF-BP3 in several diseases have been found, such as cancer, dwarfism, or acromegaly.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Inhibition of IGF-2–induced proliferation of MCF-7 cells
  • research grade: ≥ 5×
    10
    3
    U/mg
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Product options: 1
E. coli
25 µg
EUR  190,00