Clone REAL1161 is an antibody fragment derived from the full LYVE-1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1161 recognizes the human LYVE-1 protein, also known as lymphatic vessel endothelial hyaluronic acid receptor 1, LYVE1, XLKD1 or CRSBP-1. LYVE-1 is a type I integral membrane glycoprotein, which is a lymph-specific receptor for hyaluronan and homologous to CD44. LYVE-1 is mainly expressed in endothelial cells lining lymphatic vessels, but also in normal hepatic blood sinusoidal endothelial cells. LYVE-1 is an indicator for human hepatocellular carcinoma. It is involved in lymphatic hyaluronan transport, in tumor metastasis and autocrine regulation of cell growth. Lyve-1 is expressed in liver cancer.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
