Clone:
REA381
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
IFNGR2, IFGR2, Ifgt, AF-1, IFNGRB, IFNGT1, IFNγ R2, IFNγ Rβ

Specifications for IFN-γR β chain Antibody, anti-mouse, REAfinity™

Overview

Clone REA381 recognizes the mouse IFN-γ receptor β chain antigen, a type 1 transmembrane protein also known as IFN-γ accessory factor 1 (AF-1). The IFN-γR β chain pairs with CD119 to form the IFN-γ receptor. It is expressed at low levels on T and B cells, NK cells, monocytes, macrophages, and fibroblasts. IFN-γ induces several biologic effects in target cells, including antiviral and antiproliferative responses, expression of major histocompatibility complex and of Fc receptor genes, and immunoglobulin class switching.
Additional information: Clone REA381 displays negligible binding to Fc receptors.

Alternative names

IFNGR2, IFGR2, Ifgt, AF-1, IFNGRB, IFNGT1, IFNγ R2, IFNγ Rβ

Detailed product information

Technical specifications

CloneREA381
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIFN-γR β chain
Alternative names of antigenIFNGR2, IFGR2, Ifgt, AF-1, IFNGRB, IFNGT1, IFNγ R2, IFNγ Rβ
Molecular mass of antigen [kDa]38
Distribution of antigenB cells, T cells, NK cells, macrophages, monocytes, fibroblasts
Entrez Gene ID15980
RRIDAB_2652252, AB_2652253, AB_2652254, AB_2652255, AB_2652256, AB_2652257, AB_2652258, AB_2652251

Resources for IFN-γR β chain Antibody, anti-mouse, REAfinity™

Certificates

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References for IFN-γR β chain Antibody, anti-mouse, REAfinity™

Publications

  1. Marsters, S. A. et al. (1995) Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Proc. Natl. Acad. Sci. U.S.A. 92(12): 5401-5405
  2. Hemmi, S. et al. (1994) A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Cell 76(5): 803-810
  3. Ebensperger, C. et al. (1996) Genomic organization and promoter analysis of the gene ifngr2 encoding the second chain of the mouse interferon-gamma receptor. Scand. J. Immunol. 44(6): 599-606

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