Human PDGF-AA

PDGF-AA stands for platelet derived growth factor AA. Human PDGF-AA is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Human PDGF-AA

Overview

PDGF-AA stands for platelet derived growth factor AA. Human PDGF-AA is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Human PDGF-AA can be used for a variety of applications, including:
  • MSC culture and investigation of MSC development.
  • Studies of angiogenesis.
  • Investigation of PDGFR signaling.

Detailed product information

Background information

Platelet-derived growth factor-AA (PDGF-AA) is a dimeric protein composed by two identical A subunits. The members of the PDGF family form disulfide-linked homodimers such as PDGF-AA and -BB, and one heterodimer (PDGF-AB). They are stored in platelet α-granules, and after release they signal through two receptors PDGFRα and PDGFRβ. PDGF-AA signals only through PDGFRα and induces mesenchymal cell growth, morphogenesis, and migration, and is involved in development of several cell types and tissues. A dysregulation of PDGFs was shown in diseases such as diabetes, and in deficit of bone formation and reparation.

Biological activity

  • Proliferation of BALB/c 3T3 cells
  • research grade: ≥ 3×
    10
    5
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Human PDGF-AA

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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