Clone REAL1335 is an antibody fragment derived from the full Histone H3 (tri methyl K4) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1335 recognizes the human Histone H3 (tri methyl K4), a core component of the nucleosome. Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone H3 is one of the five histones that are mainly involved in building the structure of chromatin in eukaryotic cells. Histone modifications induce changes of chromatin structure and thereby affect the accessibility of transcription factors, nuclear proteins and enzymes to genomic DNA, resulting in gene activation or repression. It is known that histone modification plays critical roles in DNA repair, DNA replication, transcription regulation, alternative splicing, chromosome condensation and some diseases including autoimmune diseases and cancers.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
