Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
PTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1

Specifications for FAK pS910 Antibody, anti-human, REAfinity™


Clone REA407 recognizes the human focal adhesion kinase (FAK) antigen phosphorylated at serine 910 (pS910). FAK is a 125 kDa non-receptor and non-membrane cytoplasmic tyrosine kinase that plays critical roles in integrin-mediated signal transductions and also participates in signaling by other cell surface receptors. In integrin-mediated cell adhesion, FAK is activated via disruption of an auto-inhibitory intra-molecular interaction between its amino terminal FERM domain and the central kinase domain. The activated FAK forms a complex with Src family kinases, which initiates multiple downstream signaling pathways through phosphorylation of other proteins to regulate different cellular functions. Those signaling pathways are identified to mediate FAK regulation of migration of various normal and cancer cells. Serine 910 (pS910) is a prominent site differentially phosphorylated in response to neurotransmitters, bioactive lipids, tumor promoters, and growth factors in intestinal epithelial cells.
Additional information: Clone REA407 displays negligible binding to Fc receptors.

Alternative names

PTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenFAK pS910
Alternative names of antigenPTK2, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, FADK 1
Molecular mass of antigen [kDa]119
Entrez Gene ID5747
RRIDAB_2921778, AB_2651716, AB_2651717, AB_2921779

Resources for FAK pS910 Antibody, anti-human, REAfinity™


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References for FAK pS910 Antibody, anti-human, REAfinity™


  1. Jiang, X. et al. (2007) Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells. Cell. Signal. 19(5): 1000-1010
  2. Zhao, X. et al. (2011) Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv. Drug Deliv. Rev. 63(8): 610-615
  3. Whitney, G. S. et al. (1993) Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. DNA Cell Biol. 12(9): 823-830

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