Clone REAL1292 is an antibody fragment derived from the full ESR1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1292 recognizes the human nuclear receptor ESR1, also known as Estrogen Receptor α or NR3A1, which is widely expressed in several tissues, including liver, lung, kidney, spleen, uterus, ovary, mammary gland, male reproductive organs, bone, heart, hypothalamus, and adipose tissue. ESR1 is a transcription factor composed of several domains, which are essential for hormone and DNA binding, and activation of transcription. Estrogen receptors play a role in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
