Clone REAL1136 is an antibody fragment derived from the full Cyclin E1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1136 recognizes the Cyclin E1, also known as CCNE1, that is a member of the highly conserved cyclin family. Cyclins are regulators of CDKs (Cyclin-dependent kinases). In a protein complex it functions as a regulatory subunit of CDK2, that is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 is present in testis and placenta and weakly expressed on bronchial epithelial cells. Mutations leads to overexpression of this gene and have been observed in many tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
