CliniMACS® Electroporator

Non-viral gene engineering in a closed system

The CliniMACS Electroporator expands the possibilities of automated closed system cell processing. As a module of the CliniMACS Prodigy® Instrument it enables flexibility in large-scale transfection of various cell types.  

The electroporation step is integrated into the automated cell manufacturing workflow of the CliniMACS Prodigy. After washing and rebuffering on the CliniMACS Prodigy, cells are transferred to the CliniMACS Electroporator. The cell suspension is divided into smaller samples and mixed with transfection material such as nucleic acids. Electroporation of the divided sample takes place in the electroporation cuvette, which is a component of the single-use CliniMACS Electroporation Tubing Set. After electroporation, cells are transferred back to the CliniMACS Prodigy for downstream cell processing. 

For complete regulatory notes click here.

Benefits

Standardized, automated process

Ensuring GMP-compliant, standardized cell transfection as part of cell manufacturing performed by the CliniMACS Prodigy

Closed system

Reduced cleanroom requirements as well as increased product and operator safety

Process optimization

Electroporation parameters can be optimized cost-effectively in small-scale experiments

Flexibility

Timely and safe transfection procedures with flexible electroporation parameters for different cell types

Features & specifications

CliniMACS Plus

Electroporation Unit

Houses the electroporation cuvette. Two LEDs indicate the different stages of the electroporation process.

Connection of large volumes

External cell products or very large volumes of cell suspensions can be connected under sterile conditions via special filters.

Sterile connection

Special filters allow the sterile connection of nucleic acids or other substances to be electroporated.

Automated cell transfer

Seamless integration into cell processing workflows on the CliniMACS Prodigy Instrument.

Bags for rebuffering and nucleic acids

Cells are kept separately from nucleic acids until electroporation to minimize degradation of nucleic acids.

CentriCult unit

Temperature controlled unit for cell processing and cell cultivation

Touch screen

Software guides the operator though interactions

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Electroporation Unit

Houses the electroporation cuvette. Two LEDs indicate the different stages of the electroporation process.

Connection of large volumes

External cell products or very large volumes of cell suspensions can be connected under sterile conditions via special filters.

Sterile connection

Special filters allow the sterile connection of nucleic acids or other substances to be electroporated.

Automated cell transfer

Seamless integration into cell processing workflows on the CliniMACS Prodigy Instrument.

Bags for rebuffering and nucleic acids

Cells are kept separately from nucleic acids until electroporation to minimize degradation of nucleic acids.

CentriCult unit

Temperature controlled unit for cell processing and cell cultivation

Touch screen

Software guides the operator though interactions

CliniMACS Plus
Dimensions:45 cm × 30 cm × 48 cm (w × d × h)
Weight:21 kg
Input voltage:24 V~ (supply by CliniMACS Prodigy)
Power consumption:42 W
Frequency:50/60 Hz
Emission sound pressure level:<70 dB(A)
Types of starting material: Leukapheresis, bone marrow, cryopreserved PSCs
Available cell processing steps: Electroporation of large volumes in small portions 
Tubing sets and accessories:Dedicated CliniMACS Prodigy Electroporation Tubing Sets and CliniMACS Electroporation buffer available
Manufacture and availability:Manufactured in Germany and shipped worldwide

Applications

Electroporator further supports flexible transfection cell processing applications on the CliniMACS Prodigy® Platform in combination with the CliniMACS Electroporator.  Visit our clinical application page to discover the variety of workflows available for the CliniMACS Prodigy.

Software

  • Standard processes – available soon 
  • Electroporation operated by the CliniMACS Prodigy with pre-programmed verified electroporation settings 
  • Customizable – providing modularity and flexible adjustment of electroporation parameters  
  • Comparable, standardized results and multi-instrument alignment for scaling out of manufacturing 
  • Log reports of processes

Support

Support at your fingertips

  • CliniMACS Technical Support for real-time assistance from our experts
  • Technical and field application support for application design
  • Instrument training at regional Miltenyi University facilities
  • Comprehensive service options provided by our globally distributed field service teams

CliniMACS Electroporator 
 

Non-viral gene engineering in a closed system 
Order no. 170-075-704

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