Clone REAL1397 is an antibody fragment derived from the full CD49b antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1397 recognizes the mouse CD49b antigen, a transmembrane glycoprotein also known as Itga2 (Integrin alpha-2). CD49 is found on activated lymphocytes, epithelial cells, and platelets. In association with CD29 (integrin beta-1) a VLA-2 complex is formed, which functions as a receptor for collagen and collagen C-propeptides, laminin, and E-cadherin.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).
