Specifications for CD267 (TACI) Antibody, anti-mouse, REAfinity™
Overview
Clone REA1227 recognizes the mouse CD267 antigen, a type III transmembrane protein receptor that binds to APRIL and BAFF and also interacts with heparan sulfate proteoglycans (HSPGs). Expression of CD267 is found on subset of T cells, marzinal zone (MZ), and B1 B cells. A dual role of TACI has been suggested in regulating B cell activation. TACI
–/–mice have high number of hyper-reactive B cells, indicating an inhibitory role of TACI. On the other hand, mice lacking TACI are unable to mount normal T cell independent type 2 (TI-2) immune response and thus suggesting a positive role in promoting B cell activation.
Additional information: Clone REA1227 displays negligible binding to Fc receptors.
Alternative names
TNFRSF13B, TACIDetailed product information
Technical specifications
| Clone | REA1227 |
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| Clonality | monoclonal |
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| Isotype | recombinant human IgG1 |
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| Isotype control | REA Control Antibody, human IgG1 |
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| Host | human cell line |
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| Type of antibody | Primary antibodies, Recombinant antibodies |
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| Species | mouse |
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| Antigen | CD267 (TACI) |
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| Alternative names of antigen | TNFRSF13B, TACI |
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| Molecular mass of antigen [kDa] | 27 |
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| Distribution of antigen | T cells, B cells |
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| Entrez Gene ID | 57916 |
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| RRID | AB_2811601, AB_2811602, AB_2811603, AB_2811600 |
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