Clone:
REA984
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
CTLA-4, CTLA4, Ly-56

Specifications for CD152 Antibody, anti-mouse, REAfinity™

Overview

Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152.
Additional information: Clone REA984 displays negligible binding to Fc receptors.

Alternative names

CTLA-4, CTLA4, Ly-56

Detailed product information

Technical specifications

CloneREA984
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenCD152
Alternative names of antigenCTLA-4, CTLA4, Ly-56
Molecular mass of antigen [kDa]21
Distribution of antigenB cells, lymphocytes, T cells
Entrez Gene ID12477
RRIDAB_2727553, AB_2727510, AB_2727554, AB_2727511, AB_2727555, AB_2727512, AB_2727552

Resources for CD152 Antibody, anti-mouse, REAfinity™

Certificates

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References for CD152 Antibody, anti-mouse, REAfinity™

Publications

  1. June, C. H. et al. (1994) The B7 and CD28 receptor families. Immunol. Today 15(7): 321-331
  2. Walunas, T. L. et al. (1994) CTLA-4 can function as a negative regulator of T cell activation. Immunity 1(5): 405-413
  3. Krummel, M. F. and Allison, J. P. (1995) CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med. 182(2): 459-465

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