Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:

Specifications for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™


Clone REA235 recognizes the CD124 antigen, a 140 kDa transmembrane glycoprotein which is also known as interleukin-4 receptor subunit alpha (IL-4Rα). CD124 is expressed on both B and T lymphocytes, and on cells of several other hematopoietic lineages, including mast cell, macrophage, and undifferentiated hematopoietic cell lines. CD124 is a receptor for both IL-4 and IL-13. The functional IL-4 receptor is formed by initial binding of IL-4 to IL-4R. Subsequent recruitment to the complex of the common γ chain, in immune cells, creates a type I receptor and, in non-immune cells, of CD213a1 (IL-13RA1) forms a type II receptor. IL-4R can also interact with the IL-13/CD213a1 complex to form a similar type II receptor. The type I IL-4 receptor complex specifically binds IL-4 whereas the type II IL-4R binds either IL-4 or IL-13. The IL-4/IL-13 responses are involved in regulating the IgE production in B cells and in alternative activation of macrophages. Binding of IL-4 to CD124 on T cells promotes differentiation of Tʜ2 cells. Clone REA235 blocks the binding of IL-4 to cells and also recognizes the soluble truncated form of CD124.
Additional information: Clone REA235 displays negligible binding to Fc receptors.

Alternative names


Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
AntigenCD124 (IL-4Rα)
Alternative names of antigenIL4RA, IL-4R
Molecular mass of antigen [kDa]85
Distribution of antigenB cells, T cells, endothelial cells
Entrez Gene ID16190
RRIDAB_2654786, AB_2654787, AB_2904705, AB_2783925

Resources for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™


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References for CD124 (IL-4Rα) Antibody, anti-mouse, REAfinity™


  1. Blum, H. et al. (1996) Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. J Immunol 157(5): 1846-1853
  2. Ohara, J. et al. (1987) Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 325(6104): 537-540
  3. Nelms, K. et al. (1999) The IL-4 receptor: signaling mechanisms and biologic functions. Annu. Rev. Immunol. 17: 701-738
  4. Mosley, B. et al. (1989) The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell 59(2): 335-348

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