Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
SEMA4D, Semacl2, SEMAJ, Semcl2, coll-4

Extended validation for CD100 Antibody, anti-mouse, REAfinity™


Fixation data
To provide an indication on how an antibody performs after fixation of cells, in-house data on staining results before and after fixation with 3.7% formaldehyde using Miltenyi Biotec antibodies are provided. Different experimental settings may lead to different results.

Specifications for CD100 Antibody, anti-mouse, REAfinity™


Clone REA322 recognizes the mouse CD100 antigen, a single-pass type I membrane protein which is also known as semaphorin 4D (Sema4D). CD100 is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. It is also overexpressed by some malignancies and plays a role in tumor-induced angiogenesis similar to vascular endothelial growth factor. CD100 is a member of a family of transmembrane and secreted proteins that have been shown to act through its receptor plexin-B1 to regulate axon growth cone guidance, lymphocyte activation, and bone density. It has been shown to interact with the B cell coreceptor CD72 for enhancing B cell receptor signaling.
Additional information: Clone REA322 displays negligible binding to Fc receptors.

Alternative names

SEMA4D, Semacl2, SEMAJ, Semcl2, coll-4

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Alternative names of antigenSEMA4D, Semacl2, SEMAJ, Semcl2, coll-4
Molecular mass of antigen [kDa]93
Distribution of antigenT cells, neurons, lymphocytes, thymocytes
Entrez Gene ID20354
RRIDAB_2654332, AB_2654333, AB_2654334, AB_2654335, AB_2654336, AB_2654337, AB_2654338, AB_2654339, AB_2654340, AB_2654331

Resources for CD100 Antibody, anti-mouse, REAfinity™


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References for CD100 Antibody, anti-mouse, REAfinity™


  1. Furuyama, T. et al. (1996) Identification of a novel transmembrane semaphorin expressed on lymphocytes. J. Biol. Chem. 271(52): 33376-33381
  2. Lu, L. et al. (2014) Changes of temporomandibular joint and semaphorin 4D/plexin-B1 expression in a mouse model of incisor malocclusion. J Oral Facial Pain Headache 28(1): 68-79
  3. Zhou, H. et al. (2014) The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4. Angiogenesis 17(1): 261-274

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