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Researchers and opinion leaders have considered a number of potential solutions to the so-called antibody-related reproducibility crisis. One is to transition from traditional monoclonal antibodies to recombinant ones.*
So, what makes recombinant antibodies better and more effective than conventional hybridoma-derived ones? We asked six experts from the flow cytometry and antibody community to share their opinion and experience with recombinant antibodies.
*Bradbury, A. and Plückthun, A. (2015) Reproducibility: Standardize antibodies used in research. Nature. 518: 27–29.
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