CD90.2 MicroBeads, mouse

CD90.2 MicroBeads, mouse

CD90.2 MicroBeads were developed for positive selection or depletion of mouse T cells from single-cell suspensions of lymphoid and non-lymphoid tissues or from peripheral blood.
This product will be discontinued soon. An updated product is available: CD90.2 MicroBeads, mouse (# 130-121-278).

Background information

The mouse CD90.2 alloantigen, also known as Thy1.2, is a pan T cell marker for the most common inbred mouse strains. These strains include BALB/c, DBA, CBA/J, C3H, C57BL/6, NZB/-, S3L and others. CD90.2 is expressed on thymocytes, peripheral T cells, on some intraepithelial T cells, and at lower levels on early hematopoietic stem cells in bone marrow.
The mouse CD90.2 antibody does not cross-react with CD90.1 (Thy1.1).

Downstream applications

T cells isolated with CD90.2 MicroBeads were used to analyze cytokine expression in a mouse model of lung fibrosis
1
or after adoptive transfer of T cells from wild type and knock-out mice into immunodeficient mice.
2
Furthermore, CD90.2 MicroBeads were used for the isolation of tumor-infiltrating T cells to evaluate their immunotherapeutic potential
3
or functional properties.
4

Columns

For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.
  • Selected references

    1. Huaux, F. et al. (2003) Dual roles of IL-4 in lung injury and fibrosis. J. Immunol. 170: 2083-2092
    2. Roggia, C. et al. (2001)
      Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss
      in vivo
      .
      Proc. Natl. Acad. Sci. U.S.A. 98: 13960-13965
    3. Prévost-Blondel, A. et al. (1998)
      Tumor-infiltrating lymphocytes exhibiting high
      ex vivo
      cytolytic activity fail to prevent murine melanoma tumor growth
      in vivo
      .
      J. Immunol. 161: 2187-2194
    4. Radoja, S. et al. (2000)
      Mice bearing late-stage tumors have normal functional systemic T cell responses
      in vitro
      and
      in vivo
      .
      J. Immunol. 164: 2619-2623
Product options: 2
for 2×
10
9
total cells
EUR 600,00 
for 2×
10
9
total cells
EUR 600,00 

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