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Antigen-specific T cells play a pivotal role in fighting viral infections. Assessment of specificity, phenotype, and functional cytokine secretion of virus-activated T cells provides essential information on infection progression and the reactivity of the immune system.
However, assessment of ag-specific T cells is challenging as they constitute an extremely rare subset. Thus, a precise and sensitive analytic means is indispensable.
By performing multicolor flow analysis COVID-19 Zheng et al. recently reported that elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood of COVID-19 patients may predict severe progression (PMID: 32203186).
Benefit for our REAfinity antibodies listed below to improve and simplify your flow cytometric analysis of ag-specific T cells.
|T cell subsets||CD45|
|Cytolytic molecules||Granzyme A|
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