Clone:
REA925
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
Wilms tumor protein, WT33

Specifications for WT1 Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA925 recognizes the human and mouse WT1 protein, also known as Wilms Tumor Protein 1 or Wilms tumor suppressor protein. WT1 is a transcription factor with four zinc fingers with distinct splicing isoforms. It plays an important role in cellular development and cell survival, especially in the development of the urogenital system. Furthermore, WT1 has a tumor suppressor and oncogenic role in tumor formation. WT1 is mainly expressed in kidney and on a subset of hematopoietic cells.
Additional Information: Clone REA925 displays negligible binding to Fc receptors.

Alternative names

Wilms tumor protein, WT33

Detailed product information

Technical specifications

CloneREA925
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenWT1
Alternative names of antigenWilms tumor protein, WT33
Molecular mass of antigen [kDa]49(same molecular weight for human and mouse/rat)
Distribution of antigenother, kidney
Entrez Gene ID7490, 22431
RRIDAB_2857397, AB_2857398, AB_2857396

References for WT1 Antibody, anti-human/mouse, REAfinity™

Publications

  1. Call, K. M. et al. (1990) Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 60(3): 509-520
  2. Hamilton, T. B. et al. (1995) High affinity binding sites for the Wilms' tumour suppressor protein WT1. Nucleic Acids Res. 23(2): 277-284
  3. Smolen, G. A. et al. (2004) SUMO-1 modification of the Wilms' tumor suppressor WT1. Cancer Res. 64(21): 7846-7851

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