Clone:
REA708
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Underphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB

Specifications for Under-phospho Rb Antibody, anti-human, REAfinity™

Overview

Clone REA708 recognizes the human Under-phospho Rb, also known as underphosphorylated Rb protein (retinoblastoma protein). The retinoblastoma protein is a nuclear phosphoprotein which acts as a tumor suppressor in normal cells. The underphosphorylated, active form of the retinoblastoma protein is present in resting or completely differentiated cells and can interact with E2F1 and represses its transcription activity, which leads to cell cycle arrest. The phosphorylated forms of retinoblastoma protein are found in proliferating cells.
Additional information: Clone REA708 displays negligible binding to Fc receptors.

Alternative names

Underphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB

Detailed product information

Technical specifications

CloneREA708
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenUnder-phospho Rb
Alternative names of antigenUnderphosphorylated retinoblastoma protein, Retinoblastoma-associated protein, p105-Rb, pRb, RB, pp110, Underphosphorylated RB
Molecular mass of antigen [kDa]106
Entrez Gene ID5925
RRIDAB_2654259, AB_2654260, AB_2654261, AB_2654262, AB_2654263, AB_2654258

References for Under-phospho Rb Antibody, anti-human, REAfinity™

Publications

  1. Chellappan, S. et al. (1992) Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc. Natl. Acad. Sci. U.S.A. 89(10): 4549-4553
  2. Harbour, J. W. et al. (2000) Rb function in cell-cycle regulation and apoptosis. Nat. Cell Biol. 2(4): 65-67
  3. Ren, S. et al. (2004) Cyclin C/cdk3 promotes Rb-dependent G0 exit. Cell 117(2): 239-251

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