Clone:
REA430
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
NTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk

Specifications for TrkA Antibody, anti-human, REAfinity™

Overview

Clone REA430 recognizes the human TrkA antigen, a single-pass type I membrane protein which is also known as neurotrophic tyrosine kinase receptor type 1 (NTRK1). TrkA is a member of the neurotrophic tyrosine kinase receptor family and is involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation, and survival of sympathetic and nervous neurons. TrkA is the high affinity catalytic receptor for the nerve growth factor (NGF). As such, it mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. Although originally isolated from neural tissues, a growing body of evidence supports a role for TrkA in tumorigenesis in non-neural tumors, primarily carcinomas.
Additional information: Clone REA430 displays negligible binding to Fc receptors.

Alternative names

NTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk

Detailed product information

Technical specifications

CloneREA430
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTrkA
Alternative names of antigenNTRK1, MTC, TRK, TRK1, p140-TrkA, gp140trk
Molecular mass of antigen [kDa]84
Distribution of antigenneurons
Entrez Gene ID4914
RRIDAB_2751412, AB_2751430

References for TrkA Antibody, anti-human, REAfinity™

Publications

  1. Kiris, E. et al. (2014)
    TrkA
    in vivo
    function is negatively regulated by ubiquitination.
    J. Neurosci. 34(11): 4090-4098
  2. Shelton, D. L. et al. (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci. 15(1 Pt 2): 477-491
  3. Lagadec, C. et al. (2009) TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 28(18): 1960-1970

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