Clone:
REA246
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, ICC
Alternative names:
PODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin

Specifications for TRA-1-81 Antibody, anti-human, REAfinity™

Overview

Clone REA246 recognizes a carbohydrate epitope expressed on podocalyxin, which is a transmembrane sialoglycoprotein. Podocalyxin is a member of the CD34-related family of sialomucins and is recognized as a stem cell and malignancy marker. The expression of TRA-1-81 antigen is stage-specific and is lost upon differentiation of human EC and ES cells, making it a marker of undifferentiated pluripotent ES cells.
Additional information: Clone REA246 displays negligible binding to Fc receptors.

Alternative names

PODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin

Detailed product information

Technical specifications

CloneREA246
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTRA-1-81
Alternative names of antigenPODXL, Gp200, PC, PCLP, PCLP-1, Podocalyxin
Molecular mass of antigen [kDa]56
Distribution of antigenstem cells, ES and iPS cells
Entrez Gene ID5420
RRIDAB_2802023, AB_2654231, AB_2802035

References for TRA-1-81 Antibody, anti-human, REAfinity™

Publications

  1. Schopperle, W. M. et al. (2007) The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma. Stem Cells 25(3): 723-730
  2. Sekine, K. et al. (2020) Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media Sci Rep 10: 17937

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