Clone:
REA851
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
Transmembrane 4 L6 family member 1

Specifications for TM4SF1 Antibody, anti-human, REAfinity™

Overview

Clone REA851 recognizes the human TM4SF1 antigen, also known as transmembrane 4 L6 family member 1. TM4SF1 is a member of the tetraspanin family, which members are involved in signal transduction events, important for the regulation of cell development, activation, growth, and motility. It is reported, that TM4SF1 suppresses the expression of CD63 and CD82, two molecules that inhibit cell mobility. TM4SF1 is highly expressed in lung, breast, colon, and ovarian carcinomas. It is also found on some endothelial cells.
Additional information: Clone REA851 displays negligible binding to Fc receptors.

Alternative names

Transmembrane 4 L6 family member 1

Detailed product information

Technical specifications

CloneREA851
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTM4SF1
Alternative names of antigenTransmembrane 4 L6 family member 1
Molecular mass of antigen [kDa]22
Distribution of antigenendothelial cells, lung cancer cells, breast cancer cells, colorectal carcinoma cells
Entrez Gene ID4071
RRIDAB_2654204, AB_2654205, AB_2654199, AB_2654200, AB_2654201, AB_2654202, AB_2654203, AB_2654198

References for TM4SF1 Antibody, anti-human, REAfinity™

Publications

  1. Marken, J. S. et al. (1992) Cloning and expression of the tumor-associated antigen L6. Proc. Natl. Acad. Sci. U.S.A. 89(8): 3503-3507
  2. Marken, J. S. et al. (1994) Membrane topology of the L6 antigen and identification of the protein epitope recognized by the L6 monoclonal antibody. J. Biol. Chem. 269(10): 7397-7401

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