Clone:
REA999
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, SMUCKLER, TIM4, T-cell membrane protein 4

Specifications for TIM-4 Antibody, anti-mouse, REAfinity™

Overview

Clone REA999 recognizes the mouse antigen TIM-4, which is also known as T cell immunoglobulin and mucin domain-containing protein 4 or spleen, mucin-containing, knockout of lymphotoxin protein (SMUCKLER). TIM-4 is a member of the TIM gene family, which is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. In spleen, TIM-4 is expressed on antigen presenting cells such as lymphoid and myeloid dendritic cells and macrophages but not by T or B lymphocytes.

Alternative names

T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, SMUCKLER, TIM4, T-cell membrane protein 4

Detailed product information

Technical specifications

CloneREA999
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTIM-4
Alternative names of antigenT-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, SMUCKLER, TIM4, T-cell membrane protein 4
Molecular mass of antigen [kDa]35
Distribution of antigendendritic cells, macrophages
Entrez Gene ID276891
RRIDAB_2733581, AB_2733709, AB_2733710, AB_2733296, AB_2733297, AB_2732927, AB_2732928, AB_2733174, AB_2733175, AB_2733077, AB_2733078, AB_2733978, AB_2733979, AB_2733466, AB_2733467, AB_2733580

References for TIM-4 Antibody, anti-mouse, REAfinity™

Publications

  1. Shakhov, A. N. et al. (2004) SMUCKLER/TIM4 is a distinct member of TIM family expressed by stromal cells of secondary lymphoid tissues and associated with lymphotoxin signaling. Eur. J. Immunol. 34(2): 494-503
  2. Miyanishi, M. et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature 450(7168): 435-439
  3. Rodriguez-Manzanet, R. et al. (2008) TIM-4 expressed on APCs induces T cell expansion and survival. J. Immunol. 180(7): 4706-4713

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