Clone:
REA384
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MC, FC
Alternative names:
CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Specifications for TIM-1 Antibody, anti-human, REAfinity™

Overview

Clone REA384 recognizes the human T cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a single-pass type I membrane protein also known as hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). TIM-1 is widely expressed, with highest levels in kidney and testis. It is also expressed by activated T cells, B cells, natural killer T cells, and dendritic cells. The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity
in vivo
through responses mediated by Tʜ1, Tʜ2, Tʜ17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. In addition to serving as a receptor for filoviruses, human TIM-1 is reported to serve as a receptor for hepatitis A virus and a variety of flaviviruses, alphaviruses, and arenaviruses.
Additional information: Clone REA384 displays negligible binding to Fc receptors.

Alternative names

CD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1

Detailed product information

Technical specifications

CloneREA384
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTIM-1
Alternative names of antigenCD365, HAVCR, HAVcr-1, KIM-1, TIMD-1, TIM, TIM1
Molecular mass of antigen [kDa]37
Distribution of antigenT cells, NK cells, B cells, dendritic cells, kidney
Entrez Gene ID26762
RRIDAB_2654141, AB_2654142, AB_2654145, AB_2654146, AB_2654147, AB_2654148, AB_2654149, AB_2654150, AB_2654151, AB_2654152

References for TIM-1 Antibody, anti-human, REAfinity™

Publications

  1. Angiar, I. S. et al. (2014) TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity. Immunity 40(4): 542-553
  2. Feigelstock, D. et al. (1998) The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J. Virol. 72(8): 6621-6628
  3. Moller-Tank, S. et al. (2013) Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry. J. Virol. 87(15): 8327-8341

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