Clone:
REA677
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TCR Vb7.2, TCR Vbeta7.2

Specifications for TCR Vβ7.2 Antibody, anti-human, REAfinity™

Overview

Clone REA677 recognizes the human Vβ7.2 T cell receptor (TCR Vβ7.2). The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. It is suggested that T cells expressing TCRs with Vβ7.2 are protective against a pathogenic immune response in Sjögren's syndrome. TCR Vβ7.2 is expressed on a subset of α/β T cells.
Additional information: Clone REA677 displays negligible binding to Fc receptors.

Alternative names

TCR Vb7.2, TCR Vbeta7.2

Detailed product information

Technical specifications

CloneREA677
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTCR Vβ7.2
Alternative names of antigenTCR Vb7.2, TCR Vbeta7.2
Distribution of antigenT cells
RRIDAB_2653892, AB_2653893, AB_2653894, AB_2653895, AB_2653896, AB_2653897, AB_2653898, AB_2653899, AB_2653900, AB_2653891

References for TCR Vβ7.2 Antibody, anti-human, REAfinity™

Publications

  1. Zhao, T. M. et al. (1994) A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments. J. Exp. Med. 180(4): 1405-1414
  2. Manavalan, S. J. et al. (2004) Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome. Arthritis Rheum. 50(1): 187-198
  3. Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40(1): 27-36

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