Clone:
REA646
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TCR Vb3, Gm2426, Tcrb-V16

Specifications for TCR Vβ3 Antibody, anti-mouse, REAfinity™

Overview

Clone REA646 recognizes the mouse V beta 3 T cell receptor (TCR Vβ3). The T cell receptor is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ3 is a variant of the TCR β chain and is expressed on T cells having the a, b, and c haplotype of the TCR β gene complex.
Additional information: Clone REA646 displays negligible binding to Fc receptors.

Alternative names

TCR Vb3, Gm2426, Tcrb-V16

Detailed product information

Technical specifications

CloneREA646
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vβ3
Alternative names of antigenTCR Vb3, Gm2426, Tcrb-V16
Molecular mass of antigen [kDa]11
Distribution of antigenT cells
Entrez Gene ID100039790
RRIDAB_2653859, AB_2653862, AB_2653863, AB_2653864, AB_2653865, AB_2653866, AB_2653867, AB_2653868, AB_2653858

References for TCR Vβ3 Antibody, anti-mouse, REAfinity™

Publications

  1. Lee, J. S. et al. (2006)
    Antigen-specific expansion of TCR Vbeta3
    +
    CD4
    +
    T cells in the early stage of collagen-induced arthritis and its arthritogenic role in DBA/1J mice.
    J. Clin. Immunol. 26(3): 204-212
  2. Fairchild, S. et al. (1992)
    Tcrb-V3
    +
    T-cell deletion and a new mouse mammary tumor provirus, Mtv-44.
    Immunogenetics 36(3): 189-194
  3. Tomonari, K. et al. (1992)
    Tcrb-V3
    +
    T-cell deletion and a mouse mammary tumor provirus, Mtv-27.
    Immunogenetics 36(5): 302-305

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