Clone:
REA679
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
TCR Va2, TCR alpha2

Specifications for TCR Vα2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA679 recognizes the mouse Vα2 T cell receptor (TCR Vα2) of mice having the a, b, and c haplotypes. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable α and β chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules.
Additional information: Clone REA679 displays negligible binding to Fc receptors.

Alternative names

TCR Va2, TCR alpha2

Detailed product information

Technical specifications

CloneREA679
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vα2
Alternative names of antigenTCR Va2, TCR alpha2
Molecular mass of antigen [kDa]10
Distribution of antigenT cells
Entrez Gene ID100042372
RRIDAB_2653689, AB_2653690, AB_2653691, AB_2653692, AB_2653693, AB_2653694, AB_2653695, AB_2653696, AB_2653697, AB_2653698, AB_2653699, AB_2653700, AB_2653701, AB_2653688

References for TCR Vα2 Antibody, anti-mouse, REAfinity™

Publications

  1. Kubo, R. T. et al. (1989) Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. J. Immunol. 142(8): 2736-2742
  2. Grégoire, C. et al. (1991) Engineered secreted T-cell receptor alpha beta heterodimers. Proc. Natl. Acad. Sci. U.S.A. 88(18): 8077-8081

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