Clone:
REA464
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
TCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2

Specifications for TCR Vα11.1, 11.2 Antibody, anti-mouse, REAfinity™

Overview

Clone REA464 recognizes the mouse V alpha 11.1 and 11.2 T cell receptor (TCR Vα11.1, 11.2) of mice having the b (e.g., C57BL/6) and d (e.g., DBA/1, DBA/2, NZW) haplotypes, but not with the strains having the a (Balb/c) or c (e.g., SJL, NOD) haplotype. The TCR is responsible for recognizing antigens bound to major histocompatibility complex (MHC) molecules. It is a disulfide-linked membrane-anchored heterodimeric glycoprotein normally consisting of the highly variable alpha and beta chains expressed as part of a complex with the invariant CD3 chain molecules. TCR Vα elements are expressed preferentially in CD4 or CD8 subsets in a manner that is largely independent of the MHC haplotype. It is likely that the Vα elements interact preferentially with conserved regions of class I or class II molecules.
Additional information: Clone REA464 displays negligible binding to Fc receptors.

Alternative names

TCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2

Detailed product information

Technical specifications

CloneREA464
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenTCR Vα11.1, 11.2
Alternative names of antigenTCRA, AV11S2, Va11.2, Va11.2b, AV11S1, Va11.1, Va11.1b, TCR-Va11.1, 11.2
Molecular mass of antigen [kDa]16(refers to C-region of TCRa)
Distribution of antigenT cells
Entrez Gene ID110584, 110583, 21473
RRIDAB_2653679, AB_2653680, AB_2653681, AB_2653682, AB_2653683, AB_2653684, AB_2653685, AB_2653686, AB_2653687, AB_2653678

References for TCR Vα11.1, 11.2 Antibody, anti-mouse, REAfinity™

Publications

  1. Osman, G. E. et al. (1998) Expression of a type II collagen-specific TCR transgene accelerates the onset of arthritis in mice. Int. Immunol. 10(11): 1613-1622
  2. Nakajima, P. B. et al. (1992) Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-Va alleles. Immunogenetics 35(3): 190-198
  3. Osman, G. E. et al. (1999) T-cell receptor vbeta deletion and valpha polymorphism are responsible for the resistance of SWR mouse to arthritis induction. Immunogenetics 49(9): 764-772