Clone:
REA289
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
TCL1A, SYN-1, TML1, TCL1B

Specifications for TCL1 Antibody, anti-human, REAfinity™

Overview

Clone REA289 recognizes the T cell leukemia/lymphoma protein, a 14 kDa symmetrical b-barrel structure protein also known as oncogene TCL-1 or protein p14 TCL1. The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci in human T cell leukemias and lymphomas. In the lymphoid compartment, TCL1 expression is limited to CD4
-
CD8
-
CD3
-
thymocytes, CD34
+
CD19
+
pro–B cell through IgM-negative pre–B cells, as well as plasmacytoid subset of dendritic cells. The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity. Further, TCL1 is able to promote the formation of oligomeric TCL1-Akt protein complexes in which the kinase is preferentially phosphorylated and activated.
Additional information: Clone REA289 displays negligible binding to Fc receptors.

Alternative names

TCL1A, SYN-1, TML1, TCL1B

Detailed product information

Technical specifications

CloneREA289
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenTCL1
Alternative names of antigenTCL1A, SYN-1, TML1, TCL1B
Distribution of antigenB cells, thymocytes
RRIDAB_2653652, AB_2653653, AB_2653654, AB_2653655, AB_2653656, AB_2653657, AB_2653658, AB_2653659, AB_2653660, AB_2653661

References for TCL1 Antibody, anti-human, REAfinity™

Publications

  1. Virgilio, L. et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 91(26): 12530-12534
  2. Laine, J. et al. (2002) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J. Biol. Chem. 277(5): 3743-3751
  3. Laine, J. et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6(2): 395-407

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