Clone:
REA1143
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
MICS, IF, IHC
Alternative names:
SYP

Specifications for Synaptophysin Antibody, anti-mouse/rat, REAfinity™

Overview

Clone REA1143 recognizes the rat and mouse Synaptophysin, an integral membrane glycoprotein also known as major synaptic vesicle protein p38.
Synaptophysin plays a role in the regulation of short-term and long-term synaptic plasticity and is involved in structural functions. It is detected in neuroendocrine cells and in neurons, which are involved in in synaptic transmission. Furthermore Synaptophysin is used as a tumor marker for different tumors which emerge from neural and neuroendocrine tissues.
Additional information: Clone REA1143 displays negligible binding to Fc receptors.

Alternative names

SYP

Detailed product information

Technical specifications

CloneREA1143
Clonalitymonoclonal
Isotyperecombinant human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesrat, mouse, human
Cross-reactivityhuman
AntigenSynaptophysin
Alternative names of antigenSYP
Molecular mass of antigen [kDa]33,34
Distribution of antigenneurons, tumor cells, tumor
Entrez Gene ID20977, 24804
RRIDAB_2857491, AB_2857490

References for Synaptophysin Antibody, anti-mouse/rat, REAfinity™

Publications

  1. Südhof, T.C. et al. (1987) A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science 238(4830): 1142-1144
  2. Bargou, R.C. et al. (1991) The synaptophysin-encoding gene in rat and man is specifically transcribed in neuroendocrine cells. Gene 99(2): 197-204