Clone:
REA111
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
p72-Syk

Specifications for Syk Antibody, anti-human, REAfinity™

Overview

Clone REA111 recognizes Syk, a 72 kDa non-receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM, is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk.
Additional information: Clone REA111 displays negligible binding to Fc receptors.

Alternative names

p72-Syk

Detailed product information

Technical specifications

CloneREA111
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSyk
Alternative names of antigenp72-Syk
Molecular mass of antigen [kDa]72
Distribution of antigenB cells, T cells, breast
Entrez Gene ID6850
RRIDAB_2653624, AB_2653625, AB_2653628, AB_2653629, AB_2653630, AB_2653631

References for Syk Antibody, anti-human, REAfinity™

Publications

  1. Kurosaki, T. et al. (1995) Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182(6): 1815-1823
  2. Sada, K. et al. (2001) Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130: 177-186
  3. Siraganian, R. P. et al. Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38(16-18): 1229-1233

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