StemMACS™ RG108 is a selective small molecule inhibitor of DNA methyltransferase (DNMT).

Data and images for StemMACS™ RG108

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Chemical structure of StemMACS™ RG108
Chemical structure of StemMACS™ RG108

Specifications for StemMACS™ RG108

Overview

StemMACS™ RG108 is a selective small molecule inhibitor of DNA methyltransferase (DNMT).

Detailed product information

Background information

StemMACS™ RG108 is a cell permeable and selective inhibitor of DNA methyltransferase (DNMT). RG108 is a non-nucleoside inhibitor that binds non-covalently and reversible to the active center (IC50 = 115 nM). It has been used as an epigenetic modifier that induces DNA demethylation and reactivation of silenced tumor suppressor genes. In pluripotent stem cell research, RG108 can enhance reprogramming efficiency.

Applications

Published applications for RG108 include:
  • Inhibition of DNA Methyltransferase1
  • Increase of reprogramming efficiency2

Resources for StemMACS™ RG108

Documents and Protocols

References for StemMACS™ RG108

Publications

  1. Brueckner et al. (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 65: 6305-6311
  2. Shi et al. (2008) Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5): 568-574

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