StemMACS™ PD0325901 is a selective small molecule inhibitor of MEK (mitogen-activated protein kinase, MAPK/ERK kinase), a key component of the Ras/Raf/MEK/ERK signaling pathway.

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Chemical structure of StemMACS™ PD0325901
Chemical structure of StemMACS™ PD0325901

Specifications for StemMACS™ PD0325901

Overview

StemMACS™ PD0325901 is a selective small molecule inhibitor of MEK (mitogen-activated protein kinase, MAPK/ERK kinase), a key component of the Ras/Raf/MEK/ERK signaling pathway.

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Background information

PD0325901 is a derivative of the MEK inhibitor CI-1040 and shows improved cell permeability and higher potency towards ERK1/2 (IC50=0.33 nM). In pluripotent stem cell research, inhibition of the MAPK signaling pathway with PD0325901 has been used to enhance reprogramming and sustain pluripotent stem cell selfrenewal.

Applications

Published applications for PD0325901 include:
  • Naïve, ground state culture of murine ES and iPS cells (Ying et al.)
  • Improved reprogramming efficiency when combined with SB431542 and Thiazovivin (Lin et al.)

Resources for StemMACS™ PD0325901

Documents and Protocols

References for StemMACS™ PD0325901

Publications

  1. Ying, Q. L. et al. (2008) The ground state of embryonic stem cell self-renewal. Nature 453: 519-523
  2. Lin, T. et al. (2009) A chemical platform for improved induction of human iPSCs. Nat. Methods 6: 805-808

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