StemMACS™ LY411575 is a highly potent, small molecule gamma-secretase inhibitor that prevents Notch signaling.

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Chemical structure of StemMACS™ LY411575
Chemical structure of StemMACS™ LY411575

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Overview

StemMACS™ LY411575 is a highly potent, small molecule gamma-secretase inhibitor that prevents Notch signaling.

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Background information

StemMACS™ LY411575 is a selective small molecule inhibitor of gamma-secretase, a key component of the Notch signaling pathway. Inhibition of gamma-secretase by LY411575 prevents Notch processing and activation. LY411575 has been shown to promote goblet cell differentiation in mouse intestine and promotes neural differentiation in mouse embryonic stem cells.

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