Clone:
REA413
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
IL-4 Stat, STAT6B, STAT6C

Specifications for STAT6 pY641 Antibody, anti-human, REAfinity™

Overview

Clone REA413 recognizes the human signal transducer and activator of transcription 6 (STAT6) antigen phosphorylated at tyrosine 641 (pY641). STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven members of the STAT family are predominantly activated by growth factors and cytokines. STAT6 expression is found in many tissues. It is activated by two cytokines, IL-4 and IL-13, and plays a predominant role in the immune system. Once these cytokines bind to their cognate receptors, the associated janus kinases are activated and phosphorylate conserved tyrosine residues on the receptor. Once phosphorylated, STAT6 forms homodimers and translocates to the nucleus. In the nucleus, STAT6 has the ability to bind directly to DNA via a DNA-binding domain and is able to regulate transcription. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis.
Additional information: Clone REA413 displays negligible binding to Fc receptors.

Alternative names

IL-4 Stat, STAT6B, STAT6C

Detailed product information

Technical specifications

CloneREA413
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSTAT6 pY641
Alternative names of antigenIL-4 Stat, STAT6B, STAT6C
Molecular mass of antigen [kDa]94
Distribution of antigenother
Entrez Gene ID6778
RRIDAB_2653597, AB_2653598, AB_2653599, AB_2653600, AB_2653601, AB_2653602, AB_2653603, AB_2653596

References for STAT6 pY641 Antibody, anti-human, REAfinity™

Publications

  1. Hou, J. et al. (1994) An interleukin-4-induced transcription factor: IL-4 Stat. Science 265(5179): 1701-1706
  2. Quelle, F. W. et al. (1995) Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15(6): 3336-3343
  3. Zhou, L. et al. (2012) STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg. Med. Chem. 20(2): 750-758

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