Clone:
REA855
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC

Specifications for STAT4 pY693 Antibody, anti-human, REAfinity™

Overview

Clone REA855 recognizes the human signal transducer and activator of transcription 4 (STAT4) antigen phosphorylated at tyrosine 693 (pY693). STAT4 is a member of signal transducers and activators of the transcription (STAT) family. STAT proteins transmit signals from a receptor complex to the nucleus and activate gene expression. The seven STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon α (IFN-α), interferon γ (IFN-γ), EGF, PDGF, and interleukin 6 (IL-6)). STAT4 is involved in the development of Tʜ1 cells from naive CD4
+
T cells and IFN-γ production in response to IL-12.
Additional information: Clone REA855 displays negligible binding to Fc receptors.

Detailed product information

Technical specifications

CloneREA855
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSTAT4 pY693
Molecular mass of antigen [kDa]86
Distribution of antigenT cells
Entrez Gene ID6775
RRIDAB_2726662, AB_2726747, AB_2726663, AB_2726748, AB_2726664, AB_2726749, AB_2726665, AB_2726746

References for STAT4 pY693 Antibody, anti-human, REAfinity™

Publications

  1. Yamamoto, K. et al. (1994) Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. Mol. Cell. Biol. 14(7): 4342-4349
  2. Bacon, C. M. et al. (1995) Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 92(16): 7307-7311
  3. Kaplan, M. H. (2005)
    STAT4: a critical regulator of inflammation
    in vivo
    .
    Immunol. Res. 31(3): 231-242

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