Clone:
REA272
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Specifications for STAT1 N-terminus Antibody, anti-human, REAfinity™

Overview

Clone REA272 recognizes the N-terminus of the signal transducer and activator of transcription 1-α/β (STAT1) antigen, regardless of phosphorylation status. STAT1 is expressed in two alternatively spliced isoforms (91 kDa STAT1α and 84 kDa STAT1β) and clone REA272 recognizes both isoforms. STAT1 expression is found ubiquitously. It is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to interferon γ (IFN-γ) stimulation, the STAT1 subunits become tyrosine-phosphorylated at Y701, and the complex is translocated to the nucleus. STAT1 forms homodimers or heterodimers with STAT3 that bind to the IFN-γ activated sequence promoter element. In response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the interferon stimulated response promoter element. In either case, binding of the promoter element leads to an increased expression of interferon stimulated genes.
Additional information: Clone REA272 displays negligible binding to Fc receptors.

Alternative names

CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91

Detailed product information

Technical specifications

CloneREA272
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivitymouse, rat, dog, chicken, frog
AntigenSTAT1 N-terminus
Alternative names of antigenCANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Molecular mass of antigen [kDa]87
Entrez Gene ID6772
RRIDAB_2653556, AB_2653557

References for STAT1 N-terminus Antibody, anti-human, REAfinity™

Publications

  1. Gimeno, R. et al. (1996)
    STAT1 implication in the immune response to superantigens
    in vivo.
    J. Immunol. 156: 1378-1386
  2. Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344
  3. Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076
  4. ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668

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