Clone:
REAL956
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
SIH, SRIH, GHIH, GHRIH, SST, SST-28, SST-14, NST

Specifications for Somatostatin Antibody, anti-human, REAdye_lease™

Overview

Clone REA956 is an antibody fragment derived from the full Somatostatin antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL956 recognizes Somatostatin, also known as SIH (somatotropin (release)-inhibiting hormone) or GHIH (growth hormone (release)-inhibiting hormone)) or by several other names. Somatostatin is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin inhibits the secretion of several hormones, including growth hormone, thyroid stimulating hormone, cholecystokinin, insulin and glucogon. It also inhibits the activity of the gastrointestinal tract and the rapid reproduction of normal and tumour cells. Somatostatin may also act as a neurotransmitter in the nervous system.
Synthetic analogs of Somatostatin are used for the treatment of a variety of disorders including acromegaly and the symptomatic treatment of carcinoid tumors and vasoactive intestinal peptide tumors.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

SIH, SRIH, GHIH, GHRIH, SST, SST-28, SST-14, NST

Detailed product information

Technical specifications

CloneREAL956
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenSomatostatin
Alternative names of antigenSIH, SRIH, GHIH, GHRIH, SST, SST-28, SST-14, NST
Distribution of antigenpancreas

References for Somatostatin Antibody, anti-human, REAdye_lease™

Publications

  1. Bhandari, S. et al. (2008) Expression of Somatostatin and Somatostatin Receptor Subtypes 1–5 in Human Normal and Diseased Kidney. J Histochem Cytochem 56(8): 733-743
  2. Moatassim-Billah, S. et al. (2016) Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts. Oncotarget. 7(27): 41584-4198

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