Clone:
REA1050
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC, MICS, IF, IHC, MC
Alternative names:
SELPLG, CD162, CLA, PSGL-1, PSGL1

Specifications for Slan (M-DC8) Antibody, anti-human, REAfinity™

Overview

Clone REA1050 recognizes the human 6-sulfo LacNAc (Slan) (M-DC8) antigen, which is a carbohydrate modification of P-selectin glycoprotein ligand-1 (PSGL-1). This antigen is characteristically expressed on a new subset of peripheral blood mononuclear cells (PBMCs) with features closely related to CD16
+
CD14
low
monocytes. Slan (M-DC8)
+
cells constitute 0.5–2% of all PBMCs with similar frequencies among mononuclear cells from cord blood.
Additional information: Clone REA1050 displays negligible binding to Fc receptors.

Alternative names

SELPLG, CD162, CLA, PSGL-1, PSGL1

Detailed product information

Technical specifications

CloneREA1050
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenSlan (M-DC8)
Alternative names of antigenSELPLG, CD162, CLA, PSGL-1, PSGL1
Molecular mass of antigen [kDa]39
Distribution of antigenmonocytes
Entrez Gene ID6404
RRIDAB_2751439, AB_2751442, AB_2751440, AB_2801906, AB_2751441

References for Slan (M-DC8) Antibody, anti-human, REAfinity™

Publications

  1. Schäkel, K. et al. (1998)
    A novel dendritic cell population in human blood: one-step immunomagnetic isolation by a specific mAb (M-DC8) and
    in vitro
    priming of cytotoxic T lymphocytes.
    Eur. J. Immunol. 28: 4084-4093
  2. de Baey, A. et al. (2001)
    Phenotype and function of human dendritic cells derived from M-DC8
    +
    monocytes.
    Eur. J. Immunol. 31: 1646-1655
  3. Schäkel, K. et al. (2002) 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells. Immunity 17: 289-301

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