Clone:
ES22-10D8
Type of antibody:
Primary antibodies
Isotype:
rat IgG1
Applications:
FC, MICS, IF, IHC
Alternative names:
SIGLECF, SIGLEC5, mSiglec-F

Specifications for Siglec-F Antibody, anti-mouse

Overview

The monoclonal antibody ES22-10D8 recognizes mouse sialic acid-binding immunoglobulin-like lectin F (siglec-F), which is a member of the Ig superfamily containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. In mouse, siglec-F is an inhibitory receptor on eosinophils. It recognizes preferentially the glycan ligand 6'-sulfated sialyl Lewis X.

Alternative names

SIGLECF, SIGLEC5, mSiglec-F

Detailed product information

Technical specifications

CloneES22-10D8
Clonalitymonoclonal
Isotyperat IgG1
Isotype controlIsotype Control Antibody, rat IgG1
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenSiglec-F
Alternative names of antigenSIGLECF, SIGLEC5, mSiglec-F
Molecular mass of antigen [kDa]60
Entrez Gene ID233186
RRIDAB_2733493, AB_2811558, AB_2653451, AB_2653453, AB_2653454, AB_2733492

Reviews for Siglec-F Antibody, anti-mouse

Adequate Siglec-F staining

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Anti-Siglec-F-PE, mouse (130-102-274)

Mice were IP injected with zymosan and peritoneal leukocytes were recovered by lavage 2 days later. Total recovered cells were stained to identify eosinophils.

References for Siglec-F Antibody, anti-mouse

Publications

  1. Zhang, M. et al. (2007)
    Defining the
    in vivo
    function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils.
    Blood 109(10): 4280-4287
  2. Guo, J. P. et al. (2011) Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am. J. Respir. Cell Mol. Biol. 44(2): 238-243
  3. Tateno, H. et al. (2005) Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6-sulfo-sialyl Lewis X as a preferred glycan ligand. Glycobiology 15(11): 1125-1135

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