Clone:
5G6
Type of antibody:
Primary antibodies
Isotype:
mouse IgG1κ
Applications:
FC
Alternative names:
PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Specifications for Siglec-10 Antibody, anti-human

Overview

Clone 5G6 recognizes the sialic acid-binding Ig-like lectin 10 (Siglec-10) antigen, a member of the CD33-related group of siglecs. The cytoplasmic tail of Siglec-10 contains four tyrosines, two of which are embedded in ITIM-signaling motifs and are likely to be involved in intracellular signaling. Amongst peripheral blood leucocytes, Siglec-10 was found to be expressed on eosinophils, monocytes, and B cells. Higher levels of Siglec-10 were found on a minor subset of NK-like cells that express the CD16 low-affinity Fc receptor but lack the CD56 antigen. The molecular properties and expression pattern suggest that Siglec-10 may have evolved to function as an inhibitory receptor of the innate immune system.

Alternative names

PRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)

Detailed product information

Technical specifications

Clone5G6
Clonalitymonoclonal
Isotypemouse IgG1κ
Isotype controlIsotype Control Antibody, mouse IgG1
Hostmouse
Type of antibodyPrimary antibodies
Specieshuman
AntigenSiglec-10
Alternative names of antigenPRO940, SLG2, Siglec10, Siglec-like protein 2 (SLG2)
Molecular mass of antigen [kDa]75
Distribution of antigenB cells, monocytes, eosinophils
Entrez Gene ID89790
RRIDAB_2653411, AB_2653412, AB_2653413, AB_2653410

References for Siglec-10 Antibody, anti-human

Publications

  1. Bandala-Sanchez, E. et al. (2013) T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat. Immunol. 14(7): 741-748
  2. Kitzig, F. et al. (2002) Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Biochem. Biophys. Res. Commun. 296(2): 355-362
  3. Munday, J. et al. (2001) Identification, characterization, and leucocyte expression of siglec-10, a novel human sialic acid-binding receptor. Biochem. J. 355: 489-497

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