Clone:
REAL1328
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B

Specifications for S100B Antibody, anti-human/mouse, REAdye_lease™

Overview

Clone REAL1328 is an antibody fragment derived from the full S100B antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1328 recognizes the human and mouse S100B protein which controls the activation of Glial fibrillary acidic protein (GFAP), polymerization of tubulin and DNA repair. S100B is a neurotrophic factor and neuronal survival protein and is involved in neurite extension, stimulation of Ca2
+
fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. It is expressed in mature astrocytes of the brain, but also found in a variety of other cell types such as T lymphocytes, monocytes, and platelets. S100B is used as a biomarker for neurological disorders: acute brain injury, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis), congenital/perinatal disorders (Down syndrome, spinocerebellar ataxia-1) and psychiatric disorders (schizophrenia, mood disorders) .
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B

Detailed product information

Technical specifications

CloneREAL1328
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman, mouse
Cross-reactivitymouse, rat
AntigenS100B
Alternative names of antigenS100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B
Distribution of antigenastrocytes, T cells, monocytes, platelets, other

Resources for S100B Antibody, anti-human/mouse, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for S100B Antibody, anti-human/mouse, REAdye_lease™

Publications

  1. Michetti , F. et al. (2019) The S100B story: from biomarker to active factor in neural injury. J Neurochem 148(2): 168-187
  2. Langeh, U. et al. (2021) Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders. Curr Neuropharmacol. 19(2): 265-277

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