Angiotensin-converting enzyme 2 (ACE2, also known as ACEH) is a transmembrane protein and acts as receptor for SARS-CoV, SARS-CoV-2, and some other coronaviruses. The large extracellular peptidase domain of ACE2 is known to interact with the spike protein of coronaviruses. The small C-terminal collectrin-like domain (CLD) has recently been described to mediate homo-dimerization of ACE2. The main function of ACE2 is the catalytic conversion of angiotensins, thereby regulating cardiovascular homeostasis. Recombinant Human ACE2 (HEK) protein covers amino acids Q18 to S740 of human ACE2 including the C-terminal collectrin-like

Data and images for Recombinant Human ACE2 (HEK)

Figures

Figure 1

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ELISA of Recombinant Human ACE2
. Binding of biotinylated Recombinant Human ACE2 to recombinant RBD was detected. Truncated ACE2 without CLD (triangle: insect cell–derived Miltenyi Biotec product) and full length ACE2 including CLD (square: HEK-derived Miltenyi Biotec product; circle: another commercially available product) was analyzed.

Figure 1

ELISA of Recombinant Human ACE2
. Binding of biotinylated Recombinant Human ACE2 to recombinant RBD was detected. Truncated ACE2 without CLD (triangle: insect cell–derived Miltenyi Biotec product) and full length ACE2 including CLD (square: HEK-derived Miltenyi Biotec product; circle: another commercially available product) was analyzed.

Figure 2

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SDS-PAGE of biotinylated Recombinant Human ACE2 (HEK)
under reduced (R) and non-reduced (NR) conditions.

Figure 2

SDS-PAGE of biotinylated Recombinant Human ACE2 (HEK)
under reduced (R) and non-reduced (NR) conditions.

Figure 3

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Size-exclusion chromatography (SEC) of Recombinant Human ACE2 (HEK).
The non-biotinylated protein was analyzed and the peak corresponds to the multimeric protein.

Figure 3

Size-exclusion chromatography (SEC) of Recombinant Human ACE2 (HEK).
The non-biotinylated protein was analyzed and the peak corresponds to the multimeric protein.

Specifications for Recombinant Human ACE2 (HEK)

Overview

Angiotensin-converting enzyme 2 (ACE2, also known as ACEH) is a transmembrane protein and acts as receptor for SARS-CoV, SARS-CoV-2, and some other coronaviruses. The large extracellular peptidase domain of ACE2 is known to interact with the spike protein of coronaviruses. The small C-terminal collectrin-like domain (CLD) has recently been described to mediate homo-dimerization of ACE2. The main function of ACE2 is the catalytic conversion of angiotensins, thereby regulating cardiovascular homeostasis. Recombinant Human ACE2 (HEK) protein covers amino acids Q18 to S740 of human ACE2 including the C-terminal collectrin-like domain and contains a His-tag and an AviTag™. Recombinant Human ACE2 (HEK)-Biotin is specifically biotinylated at a single site, preserving full functionality of ACE2.

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