Clone:
REA270
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1

Specifications for PTEN Antibody, anti-human/mouse, REAfinity™

Overview

Clone REA270 recognizes the phosphatase and tensin homolog deleted on chromosome ten (PTEN) antigen, regardless of phosphorylation status. PTEN is a tumor suppressor gene which is also known as mutated in multiple advanced cancers 1 (MMAC1) or TGF-β–regulated and epithelial cell-enriched phosphatase (TEP-1). It has been found to be defective in a large number of human cancers like glioblastoma, breast, and prostate. In addition, germ-line mutations in PTEN result in the dominantly inherited disease Cowden syndrome. PTEN functions as a negative regulator of the phosphoinositide 3-kinase signaling pathway which has crucial roles in cell proliferation, survival, differentiation, and migration. The protein encoded by PTEN is a phosphatase that preferentially dephosphorylates phosphoinositide substrates.
Additional information: Clone REA270 displays negligible binding to Fc receptors.

Alternative names

BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1

Detailed product information

Technical specifications

CloneREA270
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse, rat, other
Cross-reactivityrat, dog
AntigenPTEN
Alternative names of antigenBZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Molecular mass of antigen [kDa]47
Distribution of antigenother
Entrez Gene ID5728
RRIDAB_2653286, AB_2653287, AB_2653288, AB_2653285

References for PTEN Antibody, anti-human/mouse, REAfinity™

Publications

  1. Zhang, J. et al. (2006) PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 441(7092): 518-522
  2. Jing, L. et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275(5308): 1943-1947
  3. Lewis, C. et al. (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. U.S.A. 96: 4240-4245

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