Clone:
REA408
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, mGCP, NAALADase I

Specifications for PSMA Antibody, anti-human, REAfinity™

Overview

Clone REA408 recognizes the human prostate-specific membrane antigen (PSMA) antigen, a single-pass type II membrane protein which is also known as folate hydrolase 1 (FOLH1), glutamate carboxypeptidase 2 (GCP2), or N-acetylated-alpha-linked acidic dipeptidase I (NAALADase). PSMA is a zinc metallopeptidase which catalyzes the hydrolysis of N-acetylaspartylglutamate to glutamate and N-acetylaspartate. It is expressed with low levels in the small intestine, renal tubular cells, and salivary gland, and is over-expressed in prostate cancer tissue. PSMA is also expressed in the nervous system.
Additional information: Clone REA408 displays negligible binding to Fc receptors.

Alternative names

FOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, mGCP, NAALADase I

Detailed product information

Technical specifications

CloneREA408
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (S), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenPSMA
Alternative names of antigenFOLH1, FGCP, FOLH, GCP2, GCPII, NAALAD1, PSM, mGCP, NAALADase I
Molecular mass of antigen [kDa]84
Distribution of antigenother, small intestine
Entrez Gene ID2346
RRIDAB_2734082, AB_2784448, AB_2784447, AB_2728076, AB_2728069, AB_2653279, AB_2653280, AB_2653281, AB_2653282, AB_2734081

References for PSMA Antibody, anti-human, REAfinity™

Publications

  1. Israeli, R. S. et al. (1993) Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen. Cancer Res. 53(2): 227-230
  2. Ghosh, A. et al. (2004) Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J. Cell. Biochem. 91(3): 528-539
  3. Luthi-Carter, R. et al. (1998) Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J. Pharmacol. Exp. Ther. 286(2): 1020-1025

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